BioInvest News â Nektar (NKTR) Continues Charge Forward With â181 & â214 Leading The Way. On the recent Q4 conference call, NKTR provided updates for both â181 and â214. The company has had two positive pre-NDA meetings with the FDA over the last two months regarding â181. One very important aspect discussed with the agency is a better abuse scheduling for â181 given its non-addictive properties than a Schedule 2 which is currently used for addictive opioids.